FORMULATION AND EVALUATION OF MICROCAPSULES OF TRIHEXYPHENIDYLE HYDROCHLORIDE BY SOLVENT EVAPORATION METHOD. Prepared microcapsules were evaluated for the particle size, percentage yield, incorporation efficiency, flow property and in vitro drug release at pH for 12 hours. J Microencapsul. Feb;21(1) Preparation and evaluation of microcapsules using polymerized rosin as a novel wall forming material. Fulzele SV(1). Preparation of microcapsules with the evaluation of physicochemical properties and molecular interaction. Kim KH(1), Cho SA, Lim JY, Lim DG.
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The in vitro dissolution study confirmed the Higuchi-order release pattern. The effect of variables like solvent systems, stirring speed and temperature were previously optimized.
The solution system of drug and polymerized evaluation of microcapsules dissolved in iso-propyl alcohol and acetone is sprayed with the help of a 0. A crossover experimental design with a washout period of 1 month was followed for testing the formulation.
Rats were kept for overnight fasting. Only water was permitted until 24 h following oral administration of formulation.
Microcapsules were suspended in 0. Rat dose was calculated based on the weight of evaluation of microcapsules rats. Blood samples were collected from retroorbital plexus vein from rat eye.
About two mL of blood samples was collected 0.
The clear liquid was removed and placed in Eppendorf tube. Then the supernatant was diluted with mobile phase Acetonitrile: Highest concentration of drug in plasma attained by the administrated dose is.
Time taken to reach maximum concentration of drug in plasma is. Area under the curve was calculated by using trapezoidal rule. evaluation of microcapsules
Biological half-life was calculated by using formula 0. Absorption rate constant was calculated by using method of residuals. Clearance Cl was calculated by using formula: Mean residence time was calculated based on The morphology of evaluation of microcapsules was characterized by scanning electron microscopy.
Jayakrishnan A, Latha MS.
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